Neurologist. Director of Multiple Sclerosis Centre of Catalonia (Cemcat)

  • Chairman & Director Dept. of Neurology-Neuroimmunology, Vall d’Hebron University Hospital (HUVH)
  • ​Chief of the Neuroimmunology Research Group at the Vall d’Hebron Research Institute (VHIR)
  • Vice-president of the Fundació Esclerosi Múltiple (FEM)
  • President of the Cemcat Foundation
  • Chairman International Medical & Scientific Board of the Multiple Sclerosis International Federation
  • Scientific Committee & Board Member of the European Charcot Foundation
  • Former President of the European of the Committee for Treatment and Research in Multiple Sclerosis
  • Member of the International Panel on Multiple Sclerosis Diagnostic Criteria
  • Neuroscience Topic Advisory Group ICD11 of World Health Organization
  • Professor of Neurology and Neuroimmunology Chair Director of the Faculty of Medicine, Universitat Autònoma de Barcelona
  • Co-editor/Editor for Clinical Cases, Multiple Sclerosis Journal
  • Multiple Sclerosis Area Director of Revista de Neurología

Previous positions:

Vicepresident of the Sociedad Española de Neurología (SEN), 2014-2016
Member of the Steering Committee of Magnetic Resonance Imaging in MS (MAGNIMS), 1997-2014
Member of Scientific Commitee of European School of Neuroimmunology (ESNI), 1999-2013


MD and PhD in Neuroimmunology, Universitat Autònoma de Barcelona
Postdoctoral fellowship at the Lupus Research Institute
Clinical training National Hospital for Neurology and Neurosurgery, Queen Square in London (UK)
MBA Esade Business School


2012-2016            Chairman and Director Dept. of Neurology-Neuroimmunology, Vall d’Hebron University Hospital (HUVH)
2007-2016            Director of Multiple Sclerosis Centre of Catalonia (Cemcat)
2006-2016            Professor of Neurology, Universitat Autònoma de Barcelona
2010-2012            Clinical director of Neuroscience, HUVH
2005-2010            Clinical Head, Neurology Department, HUVH
1990-2012            Director, Clinical Neuroimmunology Unit, HUVH

Projects / Lines of Research / Interests

Prof. Montalban has been in the inception phases and on steering committees of many clinical trials as an expert and key opinion leader in Multiple Sclerosis. He has authored over 400 original and revision publications in International peer-reviewed journals as well as several book chapters.

As a chief of the Neuroimmunology Research Group at the Vall d’Hebron Research Institute (VHIR), he is also working on MR imaging and biological prognostic factors of disease evolution and treatment response, immunological mechanisms of the disease and other aspects of clinical management of MS. Of note in Medicine education is the UAB postgraduate online Master's Degree in Neuroimmunology offered to physicians with some experience in the field.

His research interests include clinical aspects of MS: he has directed the development of the first Spanish (second worldwide) Multiple Sclerosis Clinical Practice Guidelines. He also has led the European Guidelines for Treatment of MS, of which Prof. R. Gold is co-chair.


Río J, Rovira A, Tintoré M, Sastre-Garriga J, Castilló J, Auger C, Nos C, Comabella M, Tur C, Vidal A, Montalbán X. Evaluating the response to glatiramer acetate in relapsing-remitting multiple sclerosis (RRMS) patients. Mult Scler. 2014 Oct;20(12):1602-8. doi: 10.1177/1352458514527863. Epub 2014 Mar 12. PubMed PMID: 24622350.

Comabella M, Montalban X. Body fluid biomarkers in multiple sclerosis. Lancet Neurol. 2014 Jan;13(1):113-26. doi: 10.1016/S1474-4422(13)70233-3. Review. PubMed PMID: 24331797.

Costa C, Arrambide G, Tintore M, Castilló J, Sastre-Garriga J, Tur C, Río J,  Saiz A, Vidal-Jordana A, Auger C, Nos C, Rovira A, Comabella M, Horga A, Montalban X. Value of NMO-IgG determination at the time of presentation as CIS. Neurology. 2012 May 15;78(20):1608-11. doi: 10.1212/WNL.0b013e3182563b32. Epub 2012 May 2. PubMed PMID: 22551725.

Tintore M, Rovira A, Arrambide G, Mitjana R, Río J, Auger C, Nos C, Edo MC,  Castilló J, Horga A, Perez-Miralles F, Huerga E, Comabella M, Sastre-Garriga J, Montalban X. Brainstem lesions in clinically isolated syndromes. Neurology. 2010  Nov 23;75(21):1933-8. doi: 10.1212/WNL.0b013e3181feb26f. PubMed PMID: 21098409.

Comabella M, Fernández M, Martin R, Rivera-Vallvé S, Borrás E, Chiva C, Julià E, Rovira A, Cantó E, Alvarez-Cermeño JC, Villar LM, Tintoré M, Montalban X. Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis. Brain. 2010 Apr;133(Pt 4):1082-93. doi: 10.1093/brain/awq035. Epub 2010 Mar 17. PubMed PMID: 20237129.

Río J, Comabella M, Montalban X. Predicting responders to therapies for multiple sclerosis. Nat Rev Neurol. 2009 Oct;5(10):553-60. doi:10.1038/nrneurol.2009.139. Review. PubMed PMID: 19794514.

Río J, Castilló J, Rovira A, Tintoré M, Sastre-Garriga J, Horga A, Nos C, Comabella M, Aymerich X, Montalbán X. Measures in the first year of therapy predict the response to interferon beta in MS. Mult Scler. 2009 Jul;15(7):848-53. doi: 10.1177/1352458509104591. PMID:19542263[PubMed - indexed for MEDLINE]

Comabella M, Craig DW, Morcillo-Suárez C, Río J, Navarro A, Fernández M, Martin R, Montalban X. Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. Arch Neurol. 2009 Aug;66(8):972-8. doi:10.1001/archneurol.2009.150. PubMed PMID: 19667218.

Rovira A, Swanton J, Tintoré M, Huerga E, Barkhof F, Filippi M, Frederiksen JL, Langkilde A, Miszkiel K, Polman C, Rovaris M, Sastre-Garriga J, Miller D,

Montalban X. A single, early magnetic resonance imaging study in the diagnosis of multiple sclerosis. Arch Neurol. 2009 May;66(5):587-92. doi:10.1001/archneurol.2009.49. PubMed PMID: 19433658.

Río J, Nos C, Tintoré M, Téllez N, Galán I, Pelayo R, Comabella M, Montalban X. Defining the response to interferon-beta in relapsing-remitting multiple sclerosis patients. Ann Neurol. 2006 Feb;59(2):344-52. PubMed PMID: 16437558.